MicroRNAs (miRNAs) are endogenous small RNAs of 21–22 nucleotides with a significant role in gene regulation. They base-pair with the 3’UTR of a targeted mRNA whilst in association with Argonaute, the effector protein of the miRNA mediated silencing complex (miRISC), and causes translation repression and/or degradation. We are interested in understanding the fundamental properties of cell intrinsic miRNA and extracellular miRNA that are found in cell free body fluids and their contribution to viral infections, disease pathologies, disease diagnosis and treatment.
Acting Assistant Teaching Professor
Biomedical Sciences and Physics (BSP) 313, Labsite
Professor Spencer seeks to to develop novel optical imaging and sensing systems for applications in tissue regeneration, transplantation, and cancer.
Current Research Topics:
Professor Subramaniam seeks to understand the fundamental physicochemical mechanisms that govern the assembly and function of biomembranes. His lab group combines experimental tools from soft matter physics, chemistry, and molecular biology to tackle cutting-edge challenges in biomembrane engineering and bottom-up synthetic biology.
Current Research Topics: