Professor Subramaniam seeks to understand the fundamental physicochemical mechanisms that govern the assembly and function of biomembranes. His lab group combines experimental tools from soft matter physics, chemistry, and molecular biology to tackle cutting-edge challenges in biomembrane engineering and bottom-up synthetic biology.
Current Research Topics:
- developing methods for high throughput fabrication of semi-synthetic cells
- developing cost effective vesicle-based therapeutics and diagnostics to improve public health
Cardiovascular diseases are the leading cause of human death all over the world. My laboratory have been focused in understanding molecular and cellular mechanisms involved in the development of cardiac arrhythmias during an increase in the heart rate (tachycardia) and after a cardiac infarction (ischemia).
Controlling the development of this cardiac arrhythmias will dramatically improve the rate of survival after a cardiac episode.
- Physiological engineering
- Molecular and cellular cardiology
- Biomedical imaging instrumentation and reconstruction algorithm development, focusing on preclinical imaging
- X-ray Luminescence Optical Tomography (XLOT)
- Simultaneous Fluorescence Optical Tomography (FOT) and Positron Emission Tomography (PET)
- Cerenkov Luminescence Imaging (CLI)/Tomography (CLT)
Professor Spencer seeks to to develop novel optical imaging and sensing systems for applications in tissue regeneration, transplantation, and cancer.
Current Research Topics:
- investigating new ways to image the thymus in live mice with subcellular resolution
- developing faster oxygen sensing methods for in vivo applications
- applying whole tissue imaging methods for studying immune reconstitution
- developing imaging assays for regenerative medicine and other applications
- Quantitative and synthetic biology
- Protein folding, evolution and design
- Protein engineering
- Optical spectroscopy
- Nuclear Magnetic Resonance spectroscopy (NMR)
- Atomic Force Microscopy (AFM)
- Laser spectroscopy and ultrafast kinetics
- Single molecule fluorescence
- Statistical mechanics
- Computational chemistry and biology
Professor Chin's studies have focused on the application of polymer physics, microfabrication and engineering principles to biological systems. The application of the theory and tools from engineering in his work has initiated many innovative and productive research projects. These studies have brought us a better understanding of natural phenomena from the unique perspective of engineering. Professor Chin's current research plans include:
- Intracellular Ca2+ signaling in acute pancreatitis, cystic fibrosis, asthma and chronic obstructive pulmonary disease
- Applications of microfabrication techniques to study microenvironment effects on stem cell differentiation
- Spontaneous polymer gel assembly in aqueous environment Intracellular and intercellular signaling in unicellular phytoplankton cells